"Role of Hydrogen Peroxide in the Cytotoxic Reaction of T Lymphocytes"
Kareen J. I. Thorne, Rosamund J. Svvennsen and D.
Clin. Exp. Immunol.
Volume 39 (2)
PMID: 6248285 [PubMed - indexed
A quote from the
"Since the killing of bacteria, viruses and certain protozoa is mediated by hydrogen
peroxide and peroxidase, the possibility exists that a similar mechanism might operate in the cytotoxicity of T lymphocytes
to target tumour cells. Hydrogen peroxide is known to be toxic to tumour cells, although different target cells appear
to differ in their sensitivity to this oxidizing agent. Hydrogen peroxide at a concentration of 5 x 10-4 M had a significant
cytotoxic activity to the P815 mastocytoma cells used in the present work. The susceptibility of tumour cells to hydrogen
peroxide is now well established. We postulate that the mastocytoma interacts with the T cell inducing the production
of hydrogen peroxide, probably at a highly localized site. This hydrogen peroxide then attacks certain sulphydryl groups
on the mastocytoma cells which initiates in the cell the serious of reactions including violent blebbing or zeiosis which
lead ultimately to its death."
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